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Comparative Study
. 2002 Mar 16;324(7338):635.
doi: 10.1136/bmj.324.7338.635.

Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white children

Peter H Whincup  1 , Julie A Gilg, Olia Papacosta, Carol Seymour, George J Miller, K G M M Alberti, Derek G Cook
Affiliations
Comparative Study

Early evidence of ethnic differences in cardiovascular risk: cross sectional comparison of British South Asian and white children

Peter H Whincup et al. BMJ. .

Abstract

Objectives: To examine whether British South Asian children differ in insulin resistance, adiposity, and cardiovascular risk profile from white children.

Design: Cross sectional study.

Setting: Primary schools in 10 British towns.

Participants: British children aged 8 to 11 years (227 South Asian and 3415 white); 73 South Asian and 1287 white children aged 10 and 11 years provided blood samples (half fasting, half after glucose load).

Main outcome measures: Insulin concentrations, anthropometric measures, established cardiovascular risk factors.

Results: Mean ponderal index was lower in South Asian children than in white children (mean difference -0.43 kg/m(3), 95% confidence interval -0.13 kg/m(3) to -0.73 kg/m(3)). Mean waist circumferences and waist:hip ratios were similar. Mean insulin concentrations were higher in South Asian children (percentage difference was 53%, 14% to 106%, after fasting and 54%, 19% to 99%, after glucose load), though glucose concentrations were similar. Mean heart rate and triglyceride and fibrinogen concentrations were higher among South Asian children; serum total, low density lipoprotein, and high density lipoprotein cholesterol concentrations were similar in the two groups. Differences in insulin concentrations remained after adjustment for adiposity and other potential confounders. However, the relations between adiposity and insulin concentrations (particularly fasting insulin) were much stronger among South Asian children than among white children.

Conclusions: The tendency to insulin resistance observed in British South Asian adults is apparent in children, in whom it may reflect an increased sensitivity to adiposity. Action to prevent non-insulin dependent diabetes in South Asian adults may need to begin during childhood.

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Figures

Figure
Figure
Regressions of log insulin concentration (fasting and after glucose load) on three measures of adiposity (ponderal index, waist circumference, waist:hip ratio) in South Asian (continuous line) and white (broken line) children
See this image and copyright information in PMC

Comment in

References

    1. Wild S, McKeigue P. Cross sectional analysis of mortality by country of birth in England and Wales, 1970-92. BMJ. 1997;314:705–710. - PMC - PubMed
    1. Balarajan R. Ethnicity and variations in mortality from coronary heart disease. Health Trends. 1996;28:45–51.
    1. McKeigue PM, Marmot MG, Adelstein AM, Hunt SP, Shipley MJ, Butler SM, et al. Diet and risk factors for coronary heart disease in Asians in north-west London. Lancet. 1985;ii:1086–1090. - PubMed
    1. McKeigue PM, Marmot MG, Syndercombe Court YD, Cottier DE, Rahman S, Riemersma RA. Diabetes, hyperinsulinaemia and coronary risk factors in Bangladeshis in east London. Br Heart J. 1988;60:390–396. - PMC - PubMed
    1. Miller GJ, Kotecha S, Wilkinson WH, Wilkes H, Stirling Y, Sanders TA, et al. Dietary and other characteristics relevant for coronary heart disease in men of Indian, West Indian and European descent in London. Atherosclerosis. 1988;70:63–72. - PubMed

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