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Review
. 2002 Apr;70(4):1667-76.
doi: 10.1128/IAI.70.4.1667-1676.2002.

Immunopathogenesis of Haemophilus ducreyi infection (chancroid)

Stanley M Spinola  1 , Margaret E Bauer, Robert S Munson Jr
Affiliations
Review

Immunopathogenesis of Haemophilus ducreyi infection (chancroid)

Stanley M Spinola et al. Infect Immun. 2002 Apr.
No abstract available

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Figures

FIG. 1.
FIG. 1.
EDDs and probabilities of papule formation (filled circles) and 95% CI (open circles) and probabilities of pustule formation (filled triangles) and 95% CI (open triangles) as predicted by logistic regression. The papule formation rate was based on a total of 243 sites from 116 volunteers who participated in human challenge trials prior to 1 January 2001. The pustule formation rate was based on a total of 220 sites that achieved a definite outcome (pustule or resolved) from 108 of the 116 volunteers.
FIG. 2.
FIG. 2.
Histopathology and localization of H. ducreyi in pustules at the clinical end point. (A and B) Hematoxylin and eosin stain demonstrating the two major components of the inflammatory response, PMNs eroding through the epidermis (A) and a perivascular infiltrate of mononuclear cells (B). (C) Confocal microscopic image of tissue stained with polyclonal anti-H. ducreyi antiserum (green) and anti-CD45 monoclonal antibody (red). Arrows point to leukocytes with associated bacteria. Note that the bacteria are found on the borders of leukocytes but not within them. (D) Transmission electron micrograph of a cluster of bacteria (large arrow) surrounded by PMNs. Arrowheads point to the membranes of the PMNs. Note that the bacteria are between PMNs and near necrotic cell debris but are not engulfed by the PMNs.
See this image and copyright information in PMC

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