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. 2002 Apr;46(4):1108-11.
doi: 10.1128/AAC.46.4.1108-1111.2002.

In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against organisms other than staphylococci

Junius Clark  1 , Joan C Fung-Tomc, Beatrice Minassian, Yuan-Hwang Tsai, Hyekyung Yang, Elizabeth Huczko, Benjamin Kolek, Susan Chaniewski, Cheryl Ferraro, Rebecca Drain, Elizabeth Gradelski, Daniel P Bonner
Affiliations

In vitro and in vivo activities of a novel cephalosporin, BMS-247243, against organisms other than staphylococci

Junius Clark et al. Antimicrob Agents Chemother. 2002 Apr.

Abstract

BMS-247243, a novel cephalosporin inhibitory for methicillin-resistant staphylococci, primarily has activity against gram-positive bacteria. The activities of BMS-247243, cefotaxime, and ceftriaxone against streptococci and Streptococcus pneumoniae were similar. BMS-247243 inhibits Enterococcus faecalis but not Enterococcus faecium. BMS-247243 also inhibits many inherently vancomycin-resistant species (Leuconstoc, Lactobacillus, Pediococcus) and anaerobic gram-positive bacteria.

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Figures

FIG. 1.
FIG. 1.
Comparative efficacies of BMS-247243 and ceftriaxone against penicillin-susceptible S. pneumoniae strain A9585 in the neutropenic murine thigh infection model.
See this image and copyright information in PMC

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