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Clinical Trial
. 2002 Apr;46(4):1125-7.
doi: 10.1128/AAC.46.4.1125-1127.2002.

Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria

Paul N Newton  1 , Michele van Vugt, Paktiya Teja-Isavadharm, Duangsuda Siriyanonda, Maneerat Rasameesoroj, Pramote Teerapong, Ronatrai Ruangveerayuth, Thra Slight, Francois Nosten, Yupin Suputtamongkol, Sornchai Looareesuwan, Nicholas J White
Affiliations
Clinical Trial

Comparison of oral artesunate and dihydroartemisinin antimalarial bioavailabilities in acute falciparum malaria

Paul N Newton et al. Antimicrob Agents Chemother. 2002 Apr.

Abstract

Plasma antimalarial activity following oral artesunate or dihydroartemisinin (DHA) treatment was measured by a bioassay in 18 patients with uncomplicated falciparum malaria. The mean antimalarial activity in terms of the bioavailability of DHA relative to that of artesunate did not differ significantly from 1, suggesting that DHA can be formulated to be an acceptable oral alternative to artesunate.

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Figures

FIG. 1.
FIG. 1.
Mean (standard error) plasma antimalarial bioactivity in DHA equivalents following artesunate (○) and DHA (•) administration to patients with acute falciparum malaria.
See this image and copyright information in PMC

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