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Comment
. 2002 Mar 15;539(Pt 3):647.
doi: 10.1113/jphysiol.2001.014829.

The TREK two P domain K+ channels

Amanda Patel  1 , Eric Honore
Affiliations
Comment

The TREK two P domain K+ channels

Amanda Patel et al. J Physiol. .
No abstract available

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Figures

Figure 1
Figure 1. TREK channels are opened by a variety of physical (stretch, acidosis and heat) and chemical stimuli (polyunsaturated fatty acids, lysophospholipids and volatile anaesthetics) and are regulated by phosphorylation
4TMS/2P subunits are believed to dimerize to form functional K+ channels. TREK channels and their functional homologue, the Aplysia S-type K+ channel, have been implicated in learning and memory. At the pathophysiological level, cell swelling, intracellular acidosis, along with the release of cellular lipids, will contribute to the opening of TREK and TRAAK channels during brain ischaemia and could represent an important neuroprotective switch.
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References

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