[Intra-amniotic administration of prostaglandin F 2 alpha, 12-methyl-prostaglandin F 2 alpha and hypertonic sodium chloride solution for induction of abortion in second-trimester pregnancy]

Abstract

The authors had performed comperative studies of the effect of the induction of abortion in late pregnancy according to the medical indications by intra-amniotic injection of 20% hypertonic NaCl saline in 26 pregnant patients, of 25 mg prostaglandin F2alpha with 6 hours' intervals in 25 patients, a single dose injection of 40 mg PGF2alpha in 27 cases and single dose injection of 2,5 mg 15-me-PGF2alpha given to 25 patients. The highest success rate was obtained with the single dose injection of 2,5 mg 15-me-PGF2alpha and the lowest success rate was obtained with 25 mg prostaglandin F2alpha with 6 hours' intervals. Despite of rather high procentage of success rate in using the hypertonic NaCl saline, this method is more dangerous in the moment of the injection of saline and complications during the abortion (water intoxication, necrosis of tissue, coagulation defects and other). The most frequently incountered side-effects in using PGs were vomiting and diarhea. Histologic examinations of the placenta revealed massive bleedings, at frequency rate being the same for prostaglandins and the hypertonic saline. The degree of isoimmunisation was lower with prostaglandins than with hypertonic NaCl saline, despite of the late dates of pregnancy termination. The intro-amniotic injection of the small volume solution of 15-me-PGF2alpha or PGF2alpha is more simpler and easier from the technical point of view than any methodic recommended for using saline and at the same time it is more effective.

PIP: The authors had performed comparative studies of the effect of the induction of abortion in late pregnancy by intraamniotic injection of 20% hypertonic NaC1 saline in 26 pregnant patients, of 25 mg prostaglandin F2alpha (PGF2alpha) at 6 hour intervals in 25 patients, a single dose of 40 mg PGF2alpha in 27 patients, and a single dose injection of 2.5 mg 15-me-PGF2alpha given to 25 patients. The highest success rate was obtained with the single dose injection of 2.5 mg 15-me-PGF2alpha and the lowest success rate was obtained with 25 mg PGF2alpha at 6 hour intervals. Despite the rather high percent of success in using the hypertonic NaCl saline, this method is more dangerous at the moment of injection and complications during the abortion (i.e., water intoxication, necrosis of tissue, coagulation defects, and others) are high. The most frequently encountered side effects when using PGs were vomiting and diarrhea. Histologic examinations of the placenta revealed massive bleedings at a frequency rate identical to PGs and hypertonic saline. The degree of isoimmunization was lower with the PGs than with hypertonic NaCl saline despite the late dates of pregnancy termination. The intraamniotic injection of the small volume solution of 15-me-PGF2alpha or PGF2alpha is simpler and easier from a technical point of view than any method recommending saline and is far more effective. (author's)