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Comment
. 2002 Mar 18;156(6):947-9.
doi: 10.1083/jcb.200202116. Epub 2002 Mar 18.

Keratinocyte junctions and the epidermal barrier: how to make a skin-tight dress

Gianfranco Bazzoni  1 , Elisabetta Dejana
Affiliations
Comment

Keratinocyte junctions and the epidermal barrier: how to make a skin-tight dress

Gianfranco Bazzoni et al. J Cell Biol. .

Abstract

Although intercellular junctions are known to be the major regulators of permeability of simple epithelia, they had not been thought to be important in regulating the permeability of stratified mammalian epithelia. Furuse et al. (2002)(this issue) demonstrate that functional tight junctions may indeed be a necessary part of the permeability barrier of the skin.

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Figures

Figure 1.
Figure 1.
The two major mechanisms, whereby epithelial cells control permeability, are schematically depicted. In simple (i.e., single-layer) epithelia, permeability predominantly follows the paracellular route and is mostly dependent on intercellular junctions. In multilayer epithelia, the permeability barrier depends on junctions and other cell structures, such as CCEs in the uppermost stratum corneum of the skin.
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References

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