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Comment
. 2002 Mar 18;195(6):F25-8.
doi: 10.1084/jem.20020602.

Harnessing a neural-immune circuit to control inflammation and shock

J Edwin Blalock  1
Affiliations
Comment

Harnessing a neural-immune circuit to control inflammation and shock

J Edwin Blalock. J Exp Med. .
No abstract available

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Figures

Figure 1.
Figure 1.
A scheme for a vagal immune circuit. (1) Bacteria, LPS, or other noncognitive stimuli are recognized by cells of the immune system and cause the production of inflammatory cytokines such as TNF. The inflammatory cytokines: (2) stimulate the afferent vagus nerve causing sickness behavior and fever; (3) and also act to cause hypotension and shock. (4) CNI-1493 or electrical stimulation of the efferent vagus nerve activates a cholinergic antiinflammatory pathway. (5) The resulting ACh inhibits immune cell production of inflammatory cytokines and consequently blocks shock and possibly afferent vagal stimulation.
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Comment on

References

    1. Good, R.A. 1981. Foreword: interactions of the body's major networks. In Psychoneuroimmunology. R. Ader, editor. Academic Press, Inc., Orlando. xvii–xix.
    1. Metal'nikov, S., and V. Chorine. 1926. Role des reflexes conditionnels dans l'immunite. Annales de l'Institute Pasteur. 40:893–900.
    1. Ader, R., and N. Cohen. 1991. The influence of conditioning on immune responses. Psychoneuroimmunology. R. Ader, D.L. Felten, and N. Cohen, editors. Academic Press, Inc., San Diego. 611–646.
    1. Keller, S.E., S.J. Schleifer, and M.K. Demetrikopoulos. 1991. Stress-induced changes in immune function in animals: hypothalamo-pituitary-adrenal influences. Psychoneuroimmunology. R. Ader, D.L. Felten, and N. Cohen, editors. Academic Press, Inc., San Diego. 771–787.
    1. Kavelaars, A., C.J. Heijnen, R. Tennekes, J.E. Bruggink, and J.M. Koolhaas. 1999. Individual behavioral characteristics of wild-type rats predict susceptibility to experimental autoimmune encephalomyelitis. Brain Behav. Immun. 13:279–286. - PubMed

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