Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2001 Dec;1(3):194-202.
doi: 10.1038/35106079.

Histone deacetylases and cancer: causes and therapies

P Marks  1 , R A Rifkind, V M Richon, R Breslow, T Miller, W K Kelly
Affiliations
Review

Histone deacetylases and cancer: causes and therapies

P Marks et al. Nat Rev Cancer. 2001 Dec.

Abstract

Together, histone acetyltransferases and histone deacetylases (HDACs) determine the acetylation status of histones. This acetylation affects the regulation of gene expression, and inhibitors of HDACs have been found to cause growth arrest, differentiation and/or apoptosis of many tumours cells by altering the transcription of a small number of genes. HDAC inhibitors are proving to be an exciting therapeutic approach to cancer, but how do they exert this effect?

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources