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Review
. 2002 Jan;2(1):28-37.
doi: 10.1038/nrc703.

Helicobacter pylori and gastrointestinal tract adenocarcinomas

Richard M Peek Jr  1 , Martin J Blaser
Affiliations
Review

Helicobacter pylori and gastrointestinal tract adenocarcinomas

Richard M Peek Jr et al. Nat Rev Cancer. 2002 Jan.

Abstract

Although gastric adenocarcinoma is associated with the presence of Helicobacter pylori in the stomach, only a small fraction of colonized individuals develop this common malignancy. H. pylori strain and host genotypes probably influence the risk of carcinogenesis by differentially affecting host inflammatory responses and epithelial-cell physiology. Understanding the host-microbial interactions that lead to neoplasia will improve cancer-targeted therapeutics and diagnostics, and provide mechanistic insights into other malignancies that arise within the context of microbially initiated inflammatory states.

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