Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Mar;19(3):307-19.
doi: 10.1006/mcne.2001.1094.

TGFbeta1 modulates the phenotype of Schwann cells at the transcriptional level

Rajeshwar Awatramani  1 , Susan Shumas, John Kamholz, Steven S Scherer
Affiliations

TGFbeta1 modulates the phenotype of Schwann cells at the transcriptional level

Rajeshwar Awatramani et al. Mol Cell Neurosci. 2002 Mar.

Abstract

We have examined the effects of transforming growth factor beta1 (TGFbeta1) on gene expression in cultured rat Schwann cells (SCs). TGFbeta1 decreased the steady-state mRNA levels of several genes that are expressed by myelinating SCs but had varied effects on the mRNA levels of NCAM, L1, GAP-43, and p75-genes that are expressed by denervated and nonmyelinating SCs. TGFbeta1 antagonized the effects of forskolin on the mRNA levels of the transcription factors Oct-6/tst-1/SCIP and Krox20. Transcriptional run-off analysis demonstrated that the effects of TGFbeta1 on gene expression occur at least in part at the level of transcription. Thus, TGFbeta1 suppresses the expression of genes that characterize the different phenotypes of SCs, and these changes occur at least in part at a transcriptional level.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources