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Clinical Trial
. 2002 Mar 1;438(1-2):15-8.
doi: 10.1016/s0014-2999(02)01290-6.

Effect of glutathione S-transferases on the survival of patients with acute myeloid leukaemia

Judith L Autrup  1 , Peter Hokland, Lars Pedersen, Herman Autrup
Affiliations
Clinical Trial

Effect of glutathione S-transferases on the survival of patients with acute myeloid leukaemia

Judith L Autrup et al. Eur J Pharmacol. .

Abstract

The objective of the study was to investigate the effect of genetic polymorphisms in glutathione S-transferases (GST) on the survival of acute myeloid leukaemia patients receiving adriamycin induction therapy. A total of 89 patients were included in the study. Patients who carried at least one GSTM1 allele had trend towards a better survival (mortality rate ratio (RR) 0.588; 95% CI 0.334-1.036) than GSTM1*0/0 patients. However, at low accumulated adriamycin dose, GSTM1*0/0 cases had a better survival than people expressing the gene (RR=6.1; 95% CI=1.2-11.0). The GSTT1 and GSTP1 genotype did not influence the survival in any of the groups.

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