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. 2002 Mar;65(3):290-4.
doi: 10.1021/np010310a.

Benzoylphloroglucinol derivatives from Hypericum scabrum

Michiko Matsuhisa  1 , Yasuhiro Shikishima, Yoshihisa Takaishi, Gisho Honda, Michiho Ito, Yoshio Takeda, Hirohumi Shibata, Tomihiko Higuti, Olimjon K Kodzhimatov, Ozodbek Ashurmetov
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Benzoylphloroglucinol derivatives from Hypericum scabrum

Michiko Matsuhisa et al. J Nat Prod. 2002 Mar.

Abstract

Nine new polyprenylated benzoylphloroglucinol derivatives, hyperibones A-I (1-9), were isolated from the aerial parts of the Uzbekistan medicinal plant Hypericum scabrum. Their structures were determined mainly on the basis of spectroscopic evidence (2D NMR and HRMS). Compounds 1, 2, and 4 showed mild in vitro antibacterial activity against methicillin-resistance Staphylococus aureus (MRSA) and methicillin-sensitive Staphylococus aureus (MSSA).

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