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Review
. 2002 Mar 19;12(6):R200-2.
doi: 10.1016/s0960-9822(02)00749-2.

Notch cleavage: Nicastrin helps Presenilin make the final cut

Eric C Lai  1
Affiliations
Free article
Review

Notch cleavage: Nicastrin helps Presenilin make the final cut

Eric C Lai. Curr Biol. .
Free article

Abstract

Presenilin is thought to be the proteolytic component of gamma-secretase, responsible for the intramembranous cleavage of substrates that include the activated Notch receptor. Recent studies have identified the novel protein Nicastrin as another essential component of the Presenilin/gamma-secretase complex.

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