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Case Reports
. 2002:2:6.
doi: 10.1186/1471-230x-2-6. Epub 2002 Mar 14.

Gastric adenocarcinoma in a patient re-infected with H. pylori after regression of MALT lymphoma with successful anti-H. pylori therapy and gastric resection: a case report

Uday C Ghoshal  1 , Debashish Guha, Santu Bandyopadhyay, Chiranjib Pal, Srikanta Chakraborty, Ujjala Ghoshal, Tamal K Ghosh, Bhaskar B Pal, Prabir K Banerjee
Affiliations
Case Reports

Gastric adenocarcinoma in a patient re-infected with H. pylori after regression of MALT lymphoma with successful anti-H. pylori therapy and gastric resection: a case report

Uday C Ghoshal et al. BMC Gastroenterol. 2002.

Abstract

Background: Helicobacter pylori (H. pylori) has been etiologically linked with primary gastric lymphoma (PGL) and gastric carcinoma (GC). There are a few reports of occurrence of both diseases in the same patients with H. pylori infection.

Case presentation: We report a patient with PGL in whom the tumor regressed after surgical resection combined with eradication of H. pylori infection. However, he developed GC on follow up; this was temporally associated with recrudescence/re-infection of H. pylori. This is perhaps first report of such occurrence.

Conclusions: Possible cause and effect relationship between H. pylori infection and both PGL and GC is discussed. This case also documents a unique problem in management of PGL in tropical countries where re-infection with H. pylori is supposed to be high.

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Figures

Figure 1
Figure 1
(A) Scanning electron microphotograph of gastric mucosa at presentation showing multiple round cells (possibly lymphocytes) but No H. pylori (× 1000). (B) Scanning electron microphotograph of gastric mucosa during re-infection showing bacillus with polar flagella suggestive of H. pylori (× 8000).
Figure 2
Figure 2
(A) Resected specimen of distal stomach showing diffuse infiltration by mononuclear cells without formation of lymphoid follicles with obvious cellular atypia and abnormal mitotic figures (H&E × 275). (B) The high power view of recurrent gastric tumor showing pleomorphic cells, abnormal mitotic figures, mucin secretion and formation of gland at places diagnostic of adenocarcinoma (H&E × 275).
Figure 3
Figure 3
Flow cytometry was performed using FACS calibur (Becton Dickinson) and data were analyzed using Cell Quest program. One parameter histogram is shown.
See this image and copyright information in PMC

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