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. 2002 Mar 26;58(6):907-11.
doi: 10.1212/wnl.58.6.907.

Increased familial risk of the psychotic phenotype of Alzheimer disease

R A Sweet  1 , V L Nimgaonkar, B Devlin, O L Lopez, S T DeKosky
Affiliations

Increased familial risk of the psychotic phenotype of Alzheimer disease

R A Sweet et al. Neurology. .

Abstract

Background: Psychotic symptoms in patients with AD (AD with psychosis [AD+P]) define a phenotype characterized by more rapid cognitive and functional decline and a liability to aggressive behaviors.

Objective: To determine if AD+P aggregates within families.

Methods: Case-control study of AD+P frequency in 461 siblings of 371 probands diagnosed with AD. All siblings were ascertained as part of a genetic investigation and also were diagnosed with AD. Statistical analysis used Generalized Estimating Equations to adjust for clustering within families.

Results: AD+P in probands was associated with a significantly increased risk for AD+P in family members (OR, 2.41; 95% CI 1.46-4.0; p = 0.0006). The correlation among siblings for AD+P status was modest: 0.16.

Conclusion: AD+P demonstrates familial aggregation. Further studies are required to investigate a possible genetic basis of AD+P.

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