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. 2002 May-Jun;17(3):137-41.
doi: 10.1159/000048026.

Second-trimester maternal pregnancy-associated plasma protein a and inhibin a levels in fetal trisomies

Hideki Watanabe  1 , Hiromi Hamada, Naoki Yamada, Tsuyoshi Ogura, Mana Obata Yasuoka, Suzuka Okuno, Yutaka Fujiki, Sohda Sohda, Takeshi Kubo
Affiliations

Second-trimester maternal pregnancy-associated plasma protein a and inhibin a levels in fetal trisomies

Hideki Watanabe et al. Fetal Diagn Ther. 2002 May-Jun.

Abstract

Objective: The aim of this study was to determine whether fetal trisomy is associated with altered levels of second-trimester maternal pregnancy-associated plasma protein A (PAPP-A) and inhibin A.

Methods: Maternal serum PAPP-A and inhibin A concentrations were measured at 15-17 weeks of gestation in 14 singleton pregnancies with fetal trisomy and in 56 matched pregnant controls.

Results: PAPP-A levels in the trisomy group were significantly lower than in controls. The inhibin A level with fetal trisomy 21 was slightly higher than the control group, but levels were not different between trisomies 18 and 13 and controls.

Conclusion: Fetal trisomies 21, 18, and 13 are associated with a reduction in second-trimester maternal PAPP-A levels; trisomies 18 and 13 are not associated with increased inhibin A levels, unlike trisomy 21.

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