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Case Reports
. 1979 Dec 1;2(11):584, 609.
doi: 10.5694/j.1326-5377.1979.tb127196.x.

Macrodosage of phenytoin

C G Meredith, M Kennedy, P M Chinwah, D N Wade
Case Reports

Macrodosage of phenytoin

C G Meredith et al. Med J Aust. .

Abstract

Large doses (up to 1200 mg) of phenytoin were required to achieve therapeutic plasma concentrations and to control post-traumatic seizures in a 62-year-old woman. The elimination half-life of phenytoin was calculated to be 3.5 hours. Frequent monitoring of the plasma concentration was essential to optimize the therapeutic control and to avoid systemic toxicity.

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