Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1975 Nov 8;4(5992):313-6.
doi: 10.1136/bmj.4.5992.313.

Absorption and metabolism of nicotine from cigarettes

A K Armitage, C T Dollery, C F George, T H Houseman, P J Lewis, D M Turner

Absorption and metabolism of nicotine from cigarettes

A K Armitage et al. Br Med J. .

Abstract

Eight men volunteers each smoked a single cirgarette containing 14C-nicotine and gave arterial blood samples during and for 50 minutes after smoking. The maximum concentration of nicotine in the arterial blood ranged from 31 to 41 mug/l in four regular cigarette smokers who inhaled. Two non-smokers achieved maximum levels of 2 and 4 mug/l. On a separate occasion two of the inhalers received 1 mg. 14C-nicotine in 10 divided doses injected intravenously. In both cases the peak arterial nicotine concentrations bore a similar relationship to the intravenous dose, as did the peak nicotine concentrations to the retained doses during smoking.

PubMed Disclaimer

References

    1. Br J Ind Med. 1965 Apr;22:139-43 - PubMed
    1. J Pharmacol Exp Ther. 1963 Jun;140:269-77 - PubMed
    1. Nature. 1968 Jan 27;217(5126):331-4 - PubMed
    1. Br J Pharmacol. 1971 Mar;41(3):521-9 - PubMed
    1. Biochemistry. 1973 Nov 20;12(24):5025-30 - PubMed

LinkOut - more resources