Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 May;67(1):88-91.
doi: 10.1002/jmv.2195.

Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy

Julie Bestman-Smith  1 , Guy Boivin
Affiliations

Herpes simplex virus isolates with reduced adefovir susceptibility selected in vivo by foscarnet therapy

Julie Bestman-Smith et al. J Med Virol. 2002 May.

Abstract

Sequential herpes simplex virus (HSV) isolates from AIDS patients receiving foscarnet therapy were evaluated for susceptibility to adefovir. Foscarnet-resistant isolates with DNA polymerase mutations in regions II, VI, and between I and VII were also associated with an important decrease in susceptibility to adefovir (mean IC50 increase: 4.6-fold compared to pre-foscarnet or wild-type isolates) suggesting that adefovir-resistant HSV could be selected in vivo by foscarnet therapy.

PubMed Disclaimer

Publication types

MeSH terms

LinkOut - more resources