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. 2002 Apr 4;4(7):1119-22.
doi: 10.1021/ol0255054.

Tuning rate of the bergman cyclization of benzannelated enediynes with ortho substituents

Igor V Alabugin  1 , Mariappan Manoharan, Serguei V Kovalenko
Affiliations

Tuning rate of the bergman cyclization of benzannelated enediynes with ortho substituents

Igor V Alabugin et al. Org Lett. .

Abstract

[reaction: see text] The Bergman cyclization of benzannelated enediynes is highly sensitive to ortho substitution. This finding opens possibilities for the rational design of conformer-specific and pH-dependent DNA-cleaving agents.

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