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. 2002 Mar 30;324(7340):763.
doi: 10.1136/bmj.324.7340.763.

Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study

Rosalind M Green  1 , Adnan Custovic, Gwen Sanderson, Jenny Hunter, Sebastian L Johnston, Ashley Woodcock
Affiliations

Synergism between allergens and viruses and risk of hospital admission with asthma: case-control study

Rosalind M Green et al. BMJ. .

Erratum in

  • BMJ 2002 May 11;324(7346):1131

Abstract

Objective: To investigate the importance of sensitisation and exposure to allergens and viral infection in precipitating acute asthma in adults resulting in admission to hospital.

Design: Case-control study.

Setting: Large district general hospital.

Participants: 60 patients aged 17-50 admitted to hospital over a year with acute asthma, matched with two controls: patients with stable asthma recruited from the outpatient department and patients admitted to hospital with non-respiratory conditions (inpatient controls).

Main outcome measures: Atopic status (skin testing and total and specific IgE), presence of common respiratory viruses and atypical bacteria (polymerase chain reaction), dust samples from homes, and exposure to allergens (enzyme linked immunosorbent assay (ELISA): Der p 1, Fel d 1, Can f 1, and Bla g 2).

Results: Viruses were detected in 31 of 177 patients. The difference in the frequency of viruses detected between the groups was significant (admitted with asthma 26%, stable asthma 18%, inpatient controls 9%; P=0.04). A significantly higher proportion of patients admitted with asthma (66%) were sensitised and exposed to either mite, cat, or dog allergen than patients with stable asthma (37%) and inpatient controls (15%; P<0.001). Being sensitised and exposed to allergens was an independent associate of the group admitted to hospital (odds ratio 2.3, 95% confidence interval 1.0 to 5.4; P=0.05), whereas the combination of sensitisation, high exposure to one or more allergens, and viral detection considerably increased the risk of being admitted with asthma (8.4, 2.1 to 32.8; P=0.002).

Conclusions: Allergens and viruses may act together to exacerbate asthma.

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References

    1. National Asthma Audit 1999/2000. London: National Asthma Campaign; 1999. pp. 12–16.
    1. Smith DH, Malone DC, Lawson KA, Okamoto LJ, Battista C, Saunders WB. A national estimate of the economic cost of asthma. Am J Respir Crit Care Med. 1997;156:787–793. - PubMed
    1. Campbell MJ, Holgate ST, Johnston SL. Trends in asthma mortality. BMJ. 1997;315:1012. - PMC - PubMed
    1. Gelber LE, Seltzer LH, Bouzoukis JK, Pollart SM, Chapman MD, Platts-Mills TA . Sensitization and exposure to indoor allergens as risk factors for asthma among patients presenting to hospital. Am Rev Resp Dis. 1993;147:573–578. - PubMed
    1. Johnston SL, Pattemore PK, Sanderson G, Smith S, Lampe F, Josephs L, et al. Community study of role of viral infections in exacerbations of asthma in 9-11 year old children. BMJ. 1995;310:1225–1229. - PMC - PubMed

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