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Clinical Trial
. 2002 Apr;40(4):1160-3.
doi: 10.1128/JCM.40.4.1160-1163.2002.

Molecular characterization of vancomycin-resistant Enterococci repopulating the gastrointestinal tract following treatment with a novel glycolipodepsipeptide, ramoplanin

L R Baden  1 , I A Critchley, D F Sahm, W So, M Gedde, S Porter, R C Moellering Jr, G Eliopoulos
Affiliations
Clinical Trial

Molecular characterization of vancomycin-resistant Enterococci repopulating the gastrointestinal tract following treatment with a novel glycolipodepsipeptide, ramoplanin

L R Baden et al. J Clin Microbiol. 2002 Apr.

Abstract

We characterized baseline and repopulating stool isolates recovered during a phase II trial of ramoplanin for the treatment of patients with stool carriage of vancomycin-resistant enterococci (VRE). Repopulation with a strain with a related genotype was found in 74, 60, and 53% of individuals in groups treated with placebo, 100 mg of ramoplanin, and 400 mg of ramoplanin, respectively. All ramoplanin-treated patients with a culture positive for VRE at day 7 had a relapse caused by a genotypically related isolate. In ramoplanin-treated patients, antibiotics with activities against anaerobic organisms were associated with positive cultures on day 7 (relative risk [RR] = 8.8; P = 0.004), and the avoidance of such antibiotics was significantly associated with culture negativity through day 21 (RR = 0.16; P = 0.02).

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Figures

FIG. 1.
FIG. 1.
Time to first positive culture by treatment allocation and strain relatedness. The three panels demonstrate the first times to positivity for VRE of a rectal swab specimen culture and the relatedness of the relapsing strain to the patient's baseline isolate by treatment allocation.
See this image and copyright information in PMC

References

    1. Baden, L. R., W. Thiemke, A. Skolnik, R. Chambers, J. Strymish, H. S. Gold, R. C. Moellering, Jr., and G. Eliopoulos. 2001. Long term colonization with vancomycin-resistant Enterococcus faecium. Clin. Infect. Dis. 33:1654-1660. - PubMed
    1. Beezhold, D. W., S. Slaughter, M. K. Hayden, M. Matushek, C. Nathan, G. M. Trenholme, and R. A. Weinstein. 1997. Skin colonization with vancomycin-resistant enterococci among hospitalized patients with bacteremia. Clin. Infect. Dis. 24:704-706. - PubMed
    1. Caufield, P. W., D. N. Allen, and N. K. Childers. 1987. In vitro susceptibilities of suspected periodontopathic anaerobes as determined by membrane transfer assay. Antimicrob. Agents Chemother. 31:1989-1993. - PMC - PubMed
    1. Donskey, C. J., T. K. Chowdhry, M. T. Hecker, C. K. Hoyen, J. A. Hanrahan, A. M. Hujer, R. A. Hutton-Thomas, C. C. Whalen, R. A. Bonomo, and L. B. Rice. 2000. Effect of antibiotic therapy on the density of vancomycin-resistant enterococci in the stool of colonized patients. N. Engl. J. Med. 343:1925-1932. - PMC - PubMed
    1. Eliopoulos, G. M., C. B. Wennersten, H. S. Gold, T. Schulin, M. Souli, M. G. Farris, S. Cerwinka, H. L. Nadler, M. Dowzicky, G. H. Talbot, and R. C. Moellering, Jr. 1998. Characterization of vancomycin-resistant Enterococcus faecium isolates from the United States and their susceptibility in vitro to dalfopristin-quinupristin. Antimicrob. Agents Chemother. 42:1088-1092. - PMC - PubMed

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