Comment on

• Early goal-directed therapy in the treatment of severe sepsis and septic shock.

  Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; Early Goal-Directed Therapy Collaborative Group. Rivers E, et al. N Engl J Med. 2001 Nov 8;345(19):1368-77. doi: 10.1056/NEJMoa010307. N Engl J Med. 2001. PMID: 11794169 Clinical Trial.