Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 Apr;159(4):657-60.
doi: 10.1176/appi.ajp.159.4.657.

An animal model of Tourette's syndrome

Jane R Taylor  1 , Syed A Morshed, Salina Parveen, Marcos T Mercadante, Lawrence Scahill, Bradley S Peterson, Robert A King, James F Leckman, Paul J Lombroso
Affiliations

An animal model of Tourette's syndrome

Jane R Taylor et al. Am J Psychiatry. 2002 Apr.

Abstract

Objective: An animal model was used to investigate an autoimmune etiology for some cases of Tourette's syndrome.

Method: Sera from 12 patients with Tourette's syndrome with high levels of antineural or antinuclear antibodies were infused bilaterally into the ventrolateral striatum of rats. Sera from 12 additional Tourette's syndrome patients and 12 normal subjects (both groups with low levels of autoantibodies) were infused for comparison. Rates of oral stereotypies were recorded by observers who were blind to the origin of the infused sera.

Results: Oral stereotypies significantly increased in the rats infused with sera from the patients with high levels of autoantibodies.

Conclusions: The results are consistent with an autoimmune etiology in a subset of cases of Tourette's syndrome.

PubMed Disclaimer

Publication types

LinkOut - more resources