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Clinical Trial
. 2002 Mar;93(3):264-70.
doi: 10.1067/moe.2002.120522.

Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solution

Miguel Angel Gonzalez-Moles  1 , Patricia Morales, Alberto Rodriguez-Archilla, Isabel Ruiz-Avila Isabel, Salvador Gonzalez-Moles
Affiliations
Clinical Trial

Treatment of severe chronic oral erosive lesions with clobetasol propionate in aqueous solution

Miguel Angel Gonzalez-Moles et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2002 Mar.

Abstract

Objective: We sought to analyze the results of topical treatment with a mouthwash of 0.05% clobetasol in aqueous solution in 30 patients with severe oral erosive lesions.

Study design: Over a 48-week period, we evaluated the evolution of pain, ulcerations, atrophy, and interference of the disease in the patient's daily life, classifying the response as complete (100% remission/recovery), excellent (75%), good (50%), poor (<50%), or failed.

Results: The pain and ulceration totally disappeared in 93.3% of cases and 90% reported a full recovery in their daily life activities. Atrophy response was complete in 28.5%, excellent in 60.7%, and good in 3.5%. Two patients showed no response to the treatment. Five patients suffered mild adverse effects (moon face and hirsutism) between week 4 and week 6 of treatment, which were speedily reversed by reducing the frequency of mouthwash.

Conclusions: Clobetasol mouthwash is a safe and efficacious option for the treatment of severe oral erosive lesions.

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Comment in

  • A chew-and-spit method of corticosteroid delivery.
    Thami GP, Bhalla M. Thami GP, et al. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003 Feb;95(2):128; author reply 129. doi: 10.1067/moe.2002.129. Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2003. PMID: 12599327 No abstract available.

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