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Review
. 2002 Apr;4(4):449-60.
doi: 10.1016/s1286-4579(02)01560-5.

Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease

Hongqi Lue  1 , Robert Kleemann, Thierry Calandra, Thierry Roger, Jürgen Bernhagen
Affiliations
Free article
Review

Macrophage migration inhibitory factor (MIF): mechanisms of action and role in disease

Hongqi Lue et al. Microbes Infect. 2002 Apr.
Free article

Abstract

Macrophage migration inhibitory factor (MIF) is a unique cytokine and critical mediator of host defenses with a role in septic shock and chronic inflammatory and autoimmune diseases. Its mechanism of action is incompletely understood. Here, we attempt to correlate current knowledge on the molecular pathways of MIF activity with its functions in immunity and disease.

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