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. 2002 Jan;335(1):7-14.
doi: 10.1002/1521-4184(200201)335:1<7::aid-ardp7>3.0.co;2-l.

Synthesis of imidazo[2,1-a]phthalazines, potential inhibitors of p38 MAP kinase. Prediction of binding affinities of protein ligands

Sylvie Mavel  1 , Isabelle Thery, Alain Gueiffier
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Synthesis of imidazo[2,1-a]phthalazines, potential inhibitors of p38 MAP kinase. Prediction of binding affinities of protein ligands

Sylvie Mavel et al. Arch Pharm (Weinheim). 2002 Jan.

Abstract

Based upon molecular modeling, the pharmacophore of potential inhibitors of p38 MAPK (mitogen-activated protein kinases) is discussed and the predictive binding affinities are calculated. Syntheses of original diarylimidazo[2,1-a]phthalazines obtained by Suzuki coupling are described.

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