Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2002 Feb;35(1):81-4.
doi: 10.1016/s0009-9120(02)00278-3.

Ubiquinone-10 content in lymphocytes of phenylketonuric patients

Catrina Colomé  1 , Rafael Artuch, Maria A Vilaseca, Cristina Sierra, Nuria Brandi, Francisco J Cambra, Nilo Lambruschini, Jaume Campistol
Affiliations
Comparative Study

Ubiquinone-10 content in lymphocytes of phenylketonuric patients

Catrina Colomé et al. Clin Biochem. 2002 Feb.

Abstract

Objectives: To investigate the ubiquinone-10 content in lymphocytes from phenylketonuric patients.

Design and methods: We compared 23 patients with 25 age-matched controls. Ubiquinone-10 was analyzed by HPLC with electrochemical detection.

Results: Ubiquinone-10 concentrations were significantly lower in patients (77-270 nmol/g of protein) compared with controls (190-550) (p < 0.001). Significantly negative correlation was observed between ubiquinone-10 and phenylalanine (r = -0.441; p < 0.05).

Conclusions: Ubiquinone-10 concentrations are decreased in lymphocytes from phenylketonuric patients. This deficiency is associated with high plasma phenylalanine concentrations.

PubMed Disclaimer

Publication types

LinkOut - more resources