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Case Reports
. 2002 Feb;61(2):152-4.
doi: 10.1034/j.1399-0004.2002.610211.x.

A patient with treatment-resistant schizophrenia and cytochrome P4502D6 gene duplication

C Kawanishi  1 , T Furuno, I Kishida, T Matsumura, K Kosaka
Affiliations
Case Reports

A patient with treatment-resistant schizophrenia and cytochrome P4502D6 gene duplication

C Kawanishi et al. Clin Genet. 2002 Feb.

Abstract

We describe a patient with treatment-resistant schizophrenia who had a duplication in the cytochrome P450IID6 (CYP2D6) gene. This severely ill 71-year-old-woman had responded poorly to several neuroleptics. Molecular genetic study revealed CYP2D6 gene duplication, which results in excessive activity of CYP2D6 that metabolizes various commonly used neuroleptics. The mutation may have contributed to treatment resistance in this case.

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