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Review
. 2002 Feb;6(1):60-5.
doi: 10.1186/cc1454. Epub 2001 Nov 26.

Bench-to-bedside review: genetic influences on meningococcal disease

Clementien L Vermont  1 , Ronald de Groot, Jan A Hazelzet
Affiliations
Review

Bench-to-bedside review: genetic influences on meningococcal disease

Clementien L Vermont et al. Crit Care. 2002 Feb.

Abstract

This review discusses the possible involvement of a variety of genetic polymorphisms on the course of meningococcal disease. It has been shown that several common genetic polymorphisms can either influence the susceptibility to meningococcal disease or can account for a higher mortality rate in patients. Gene polymorphisms concerning antibody receptors, lipopolysaccharide (LPS) binding receptors or proteins, innate complement proteins as well as cytokines and hemostatic proteins are described. The study of genetic polymorphisms might provide important insights in the pathogenesis of meningococcal disease and could make it possible to identify individuals who are at risk of either contracting or dying from meningococcal disease.

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Figures

Figure 1
Figure 1
The possible involvement of genetic polymorphisms on the course of meningococcal disease. Partially adapted from [32].
See this image and copyright information in PMC

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