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Review
. 2002 Mar 27;515(1-3):1-7.
doi: 10.1016/s0014-5793(02)02425-0.

The gift of Gab

Yan Liu  1 , Larry R Rohrschneider
Affiliations
Free article
Review

The gift of Gab

Yan Liu et al. FEBS Lett. .
Free article

Abstract

Gab proteins, including mammalian Gab1, Gab2, Gab3, Drosophila DOS and Caenorhabditis elegans Soc1, comprise a growing family of scaffolding/docking molecules involved in multiple signaling pathways mediated by receptor tyrosine kinases (RTKs) and non-RTK receptors. This paper reviews the structure/function relationships of Gab proteins and their biological roles during normal growth, differentiation and development programs.

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