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. 1970 Mar 16;7(1):90-94.
doi: 10.1016/0014-5793(70)80626-3.

Effect of distamycin a on the structure and template activity of DNA in RNA - polymerase system

P Chandra  1 , C Zimmer, H Thrum
Affiliations
Free article

Effect of distamycin a on the structure and template activity of DNA in RNA - polymerase system

P Chandra et al. FEBS Lett. .
Free article

Abstract

It is shown that native and denatured DNA form complexes with the oligopeptide-antibiotic distamycin A. The pronounced inhibition of the incorporation of AMP into RNA in the DNA directed RNA-polymerase system is due to the interference of the antibiotic with DNA.

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