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Comparative Study
. 1975 Dec 1;142(6):1455-61.
doi: 10.1084/jem.142.6.1455.

Dominant nonresponsiveness in the induction of autoimmunity to liver-specific F antigen

D M Silver, D P Lane
Comparative Study

Dominant nonresponsiveness in the induction of autoimmunity to liver-specific F antigen

D M Silver et al. J Exp Med. .

Abstract

The liver-specific F antigen, although not an autoimmunogen, can induce the production of autoantibodies in responder strains. The ability to respond is under the control of two genes, one linked to the H-2 locus of mice, the other not. Responders possessing both genes produce high anti-F titers, while the H-2-linked gene alone permits a significant but low antibody response. (Responder X nonresponder) F1 hybrids derived from parents possessing identical F molecules are nonresponders, in contrast with the dominance of responsiveness in Ir gene systems. The presence of the H-2 locus from nonresponders appears involved in the inability to respond. This is discussed in terms of self-tolerance and suppression.

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References

    1. Prog Allergy. 1975;18:43-96 - PubMed
    1. Science. 1972 Jan 21;175(4019):273-9 - PubMed
    1. Eur J Immunol. 1972 Jun;2(3):195-7 - PubMed
    1. Proc Soc Exp Biol Med. 1970 Mar;133(3):989-92 - PubMed
    1. Nature. 1968 Apr 13;218(5137):141-3 - PubMed

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