Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2002 May 17;296(5571):1323-6.
doi: 10.1126/science.1070884. Epub 2002 Apr 11.

Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

Hisashi Arase  1 , Edward S Mocarski, Ann E Campbell, Ann B Hill, Lewis L Lanier
Affiliations

Direct recognition of cytomegalovirus by activating and inhibitory NK cell receptors

Hisashi Arase et al. Science. .

Abstract

Natural killer (NK) cells express inhibitory receptors for major histocompatibility complex (MHC) class I antigens, preventing attack against healthy cells. Mouse cytomegalovirus (MCMV) encodes an MHC-like protein (m157) that binds to an inhibitory NK cell receptor in certain MCMV-susceptible mice. In MCMV-resistant mice, this viral protein engages a related activating receptor (Ly49H) and confers host protection. These activating and inhibitory receptors are highly homologous, suggesting the possibility that one evolved from the other in response to selective pressure imposed by the pathogen.

PubMed Disclaimer

Comment in

Publication types

MeSH terms