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. 2002 Apr 12;296(5566):298-300.
doi: 10.1126/science.1068883.

Decoding the patterns of self and nonself by the innate immune system

Ruslan Medzhitov  1 , Charles A Janeway Jr
Affiliations

Decoding the patterns of self and nonself by the innate immune system

Ruslan Medzhitov et al. Science. .

Abstract

The innate immune system evolved several strategies of self/nonself discrimination that are based on the recognition of molecular patterns demarcating infectious nonself, as well as normal and abnormal self. These patterns are deciphered by receptors that either induce or inhibit an immune response, depending on the meaning of these signals.

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