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. 2002 Apr 12;296(5566):343-6.
doi: 10.1126/science.1068181.

A MADS-box gene necessary for fruit ripening at the tomato ripening-inhibitor (rin) locus

Julia Vrebalov  1 , Diane Ruezinsky, Veeraragavan Padmanabhan, Ruth White, Diana Medrano, Rachel Drake, Wolfgang Schuch, Jim Giovannoni
Affiliations

A MADS-box gene necessary for fruit ripening at the tomato ripening-inhibitor (rin) locus

Julia Vrebalov et al. Science. .

Abstract

Tomato plants harboring the ripening-inhibitor (rin) mutation yield fruits that fail to ripen. Additionally, rin plants display enlarged sepals and loss of inflorescence determinacy. Positional cloning of the rin locus revealed two tandem MADS-box genes (LeMADS-RIN and LeMADS-MC), whose expression patterns suggested roles in fruit ripening and sepal development, respectively. The rin mutation alters expression of both genes. Gene repression and mutant complementation demonstrate that LeMADS-RIN regulates ripening, whereas LeMADS-MC affects sepal development and inflorescence determinacy. LeMADS-RIN demonstrates an agriculturally important function of plant MADS-box genes and provides molecular insight into nonhormonal (developmental) regulation of ripening.

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