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. 1975 Oct;45(1):69-72.
doi: 10.1530/jrf.0.0450069.

Temporary sterility produced in male mice by 5-thio-D-glucose

J R Zysk, A A Bushway, R L Whistler, W W Carlton

Temporary sterility produced in male mice by 5-thio-D-glucose

J R Zysk et al. J Reprod Fertil. 1975 Oct.

Abstract

When 5-thio-D-glucose was fed to male mice at daily dose levels greater than 30 mg/kg sperm development was completely inhibited within 3 weeks and remained so without impairment of libido for the experimental period of 7 weeks. Removal of this substance from the diet resulted in a resumption of sperm development and fertility within 5 to 8 weeks. Normal litters were sired by males which had recovered after this treatment.

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