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. 2002 May;70(5):2721-4.
doi: 10.1128/IAI.70.5.2721-2724.2002.

Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries

Morihide Mitoma  1 , Takahiko Oho, Naoko Michibata, Kaoru Okano, Yutaka Nakano, Masataka Fukuyama, Toshihiko Koga
Affiliations

Passive immunization with bovine milk containing antibodies to a cell surface protein antigen-glucosyltransferase fusion protein protects rats against dental caries

Morihide Mitoma et al. Infect Immun. 2002 May.

Abstract

Cell surface protein antigen (PAc) and glucosyltransferases (GTF) of Streptococcus mutans are major colonization factors of the organism. We prepared bovine milk containing antibodies against a fusion of the saliva-binding alanine-rich region of PAc with the glucan-binding domain of GTF-I. This study examined the effect of the immune milk on the cariogenicity of S. mutans in a rat model. Concentrated immune milk was fed to rats once a day for 55 days. The group that received immune milk had significantly less caries development than controls.

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Figures

FIG. 1.
FIG. 1.
Experimental design for examining inhibitory effects of immune milk on dental caries induction in SPF rats infected with S. mutans MT8148R.
FIG. 2.
FIG. 2.
Mean caries scores on molar teeth of SPF rats after 55 days of infection with S. mutans MT8148R. Data are means and standard deviations. ∗ and ∗∗, P < 0.05 and P < 0.01 (compared with the control group), respectively.
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