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. 2002 Feb;21(1):52-6.
doi: 10.1007/s100670200012.

Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis

L S Ou  1 , L C See, C J Wu, C C Kao, Y L Lin, J L Huang
Affiliations

Association between serum inflammatory cytokines and disease activity in juvenile idiopathic arthritis

L S Ou et al. Clin Rheumatol. 2002 Feb.

Abstract

Circulating interleukin-1beta (IL-1beta), IL-6, tumour necrosis factor-alpha (TNF-alpha), osteocalcin, and conventional parameters of inflammation were examined serially in 14 children with juvenile idiopathic arthritis (JIA) to determine any correlation with the disease activity. Serum IL-1beta was undetectable in all JIA patients. Serum IL-6, white blood cell counts, platelet counts, erythrocyte sedimentation rate and C-reactive protein levels were significantly elevated in the active phase of JIA, whereas hemoglobin levels were significantly lower. Osteocalcin levels were decreased and TNF-alpha increased in active JIA status, but these differences showed no statistical significance. We concluded that inflammatory cytokines play an important role in JIA. Monitoring IL-6 in children with JIA is useful in determining disease activity and response to therapy. These findings confirm earlier reports.

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