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Case Reports
. 2002 May;36(2):203-5.
doi: 10.1016/s0169-5002(01)00464-0.

Vasculitis due to gemcitabine

A M C J Voorburg  1 , F T van Beek, P H Th J Slee, C A Seldenrijk, F M N H Schramel
Affiliations
Case Reports

Vasculitis due to gemcitabine

A M C J Voorburg et al. Lung Cancer. 2002 May.

Abstract

We report the first occurrence of gemcitabine-induced vasculitis. It concerns a 45-year-old man diagnosed with non-small lung cancer since 2 months. After the first cycle of chemotherapy, consisting of gemcitabine and cisplatin, he developed myalgia and swelling of arms and legs with impairment of movement. This re-occurred during the second cycle of chemotherapy. Further anemia, elevated ESR and increased creatininephosphokinase. A surgical biopsy showed leucocytoclastic vasculitis and necrosis of muscle tissue. The chemotherapy was stopped and the complaints disappeared and did not return.

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  • Gemcitabine and vascular toxicity.
    Muñoz A, Mañé JM, Rubio I, Fernández R, Fuente N, Barceló R, López Vivanco G. Muñoz A, et al. Lung Cancer. 2002 Aug;37(2):229. doi: 10.1016/s0169-5002(02)00152-6. Lung Cancer. 2002. PMID: 12140148 No abstract available.

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