Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2002 Apr;109(8):987-91.
doi: 10.1172/JCI15429.

The cadherin-catenin adhesion system in signaling and cancer

Maralice Conacci-Sorrell  1 , Jacob Zhurinsky, Avri Ben-Ze'ev
Affiliations
Review

The cadherin-catenin adhesion system in signaling and cancer

Maralice Conacci-Sorrell et al. J Clin Invest. 2002 Apr.
No abstract available

PubMed Disclaimer

Figures

Figure 1
Figure 1
The dual role of β-catenin in cell adhesion and transcriptional activation. β-Catenin (β) and plakoglobin (Pg) bind to cadherin adhesion receptors, and via α-catenin (α) they associate with the actin cytoskeleton to form AJs. When the Wnt signaling pathway is inactive, free β-catenin is degraded by a complex including glycogen synthase kinase (GSK), adenomatous polyposis coli (APC), and Axin, which phosphorylate β-catenin (PP). This protein complex recruits β-TrCP, which, together with Skp1, Cul1, and the E1 and E2 ubiquitination components, mediates the ubiquitination of β-catenin (Ub) and directs it to degradation by the 26S proteasome. The binding of Wnt to Frizzled (Frz) receptors activates Wnt signaling, and disheveled (Dsh) inhibits β-catenin phosphorylation by GSK. This results in β-catenin accumulation in the nucleus, where it complexes with T cell factor (TCF) and transactivates target genes such as Cyclin D1 and Myc. Modified from ref. .
See this image and copyright information in PMC

References

    1. Ben-Ze’ev A, Geiger B. Differential molecular interactions of β-catenin and plakoglobin in adhesion, signaling and cancer. Curr Opin Cell Biol. 1998;10:629–639. - PubMed
    1. Nagafuchi A. Molecular architecture of adherens junctions. Curr Opin Cell Biol. 2001;13:600–603. - PubMed
    1. Perl A, Wilgenbus P, Dahl U, Semb H, Christofori G. A causal role for E-cadherin in the transition from adenoma to carcinoma. Nature. 1998;392:190–193. - PubMed
    1. Vleminckx K, Vakaet L, Mareel M, Fiers W, van Roy F. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role. Cell. 1991;66:107–119. - PubMed
    1. Hirohashi S. Inactivation of the E-cadherin-mediated cell adhesion system in human cancers. Am J Pathol. 1998;153:333–339. - PMC - PubMed

Publication types