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Review
. 2002 Apr;109(8):999-1006.
doi: 10.1172/JCI15468.

Integrins in invasive growth

Cord Brakebusch  1 , Daniel Bouvard, Fabio Stanchi, Takao Sakai, Reinhard Fässler
Affiliations
Review

Integrins in invasive growth

Cord Brakebusch et al. J Clin Invest. 2002 Apr.
No abstract available

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Figures

Figure 1
Figure 1
Major integrin-linked signaling pathways affecting migration. Integrin signaling stimulates Rho GTPases and thereby induces changes in the cytoskeletal organization that are required for cell migration. Ligand binding to integrins also promotes cell contractility through the activation of the tyrosine kinase Erk.
Figure 2
Figure 2
Integrin control of proliferation. Synergistic activation of Ras and Rho GTPases by integrins and growth factors is necessary for cell cycle progression. Activation of Rac1, Cdc42, and RhoA can facilitate activation of Erk via Ras. Erk, as well as JNK and ILK, can induce expression of cyclin D1, thus promoting cell cycle progression. In addition, integrins can promote proliferation by inhibiting cell cycle inhibitors like p21cip and p27kip.
Figure 3
Figure 3
Integrin control of cell survival. Integrin activation of Akt via PI3-K or ILK plays an important role in the antiapoptotic effect of integrin-mediated adhesion. Activation of Erk and JNK likewise contributes to increased cell survival.
See this image and copyright information in PMC

References

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