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Case Reports
. 1975 Sep 1;53(17):835-7.
doi: 10.1007/BF01466756.

[Perimembranous glomerulonephritis after treatment with D-penicillamine. Report on 31 cases (author's transl)]

[Article in German]
H V Gärtner, G H Neild, A Bohle, W Hallauer, G Hoppe-Seyler, F M Lüttgen, P Schollmeyer
Case Reports

[Perimembranous glomerulonephritis after treatment with D-penicillamine. Report on 31 cases (author's transl)]

[Article in German]
H V Gärtner et al. Klin Wochenschr. .

Abstract

This report includes 31 patients who developed a perimembranous glomerulonephritis generally 7 months after the onset of the treatment of various illnesses with D-Penicillamine. In all cases the patients had a proteinuria, associated with a hematuria in 12 cases. After the treatment was stopped 8 patients rapidly developed a nephrotic syndrome, while its onset was more gradual in 12 other patients. 5 patients initially with a nephrotic syndrome had no proteinuria at the time of a second biopsy made up to 12 months later. In these 5 cases the typical changes of perimembranous glomerulonephritis observed on electron microscopy were much reduced in the second biopsy.

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