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Comparative Study
. 2002 May;46(5):1581-2.
doi: 10.1128/AAC.46.5.1581-1582.2002.

In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes

Qiu N Sun  1 , Annette W Fothergill, Dora I McCarthy, Michael G Rinaldi, John R Graybill
Affiliations
Comparative Study

In vitro activities of posaconazole, itraconazole, voriconazole, amphotericin B, and fluconazole against 37 clinical isolates of zygomycetes

Qiu N Sun et al. Antimicrob Agents Chemother. 2002 May.

Abstract

In vitro antifungal susceptibility testing results of a new antifungal triazole, posaconazole (POS), were compared to results with amphotericin B (AMB), itraconazole (ITC), voriconazole (VRC), and fluconazole (FLC) against clinical agents of zygomycosis. The MICs of POS at which 50% and 90% of the isolates were inhibited were 0.25 and 4 microg/ml, respectively. POS was significantly more active than VRC and FLC and slightly more active than ITC. The results suggest that POS has significant potential for clinical development against the zygomycetes.

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