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. 2002 May;46(5):1607-9.
doi: 10.1128/AAC.46.5.1607-1609.2002.

Gemifloxacin is efficacious against penicillin-resistant and quinolone-resistant pneumococci in experimental meningitis

Philippe Cottagnoud  1 , Fernando Acosta, Marianne Cottagnoud, Martin G Täuber
Affiliations

Gemifloxacin is efficacious against penicillin-resistant and quinolone-resistant pneumococci in experimental meningitis

Philippe Cottagnoud et al. Antimicrob Agents Chemother. 2002 May.

Abstract

In experimental rabbit meningitis, gemifloxacin penetrated inflamed meninges well (22 to 33%) and produced excellent bactericidal activity (change in log(10) [Deltalog(10)] CFU/ml/h, -0.68 +/- 0.30 [mean and standard deviation]), even superior to that of the standard regimen of ceftriaxone plus vancomycin (-0.49 +/- 0.09 deltalog(10) CFU/ml/h), in the treatment of meningitis due to a penicillin-resistant pneumococcal strain (MIC, 4 mg/liter). Even against a penicillin- and quinolone-resistant strain, gemifloxacin showed good bactericidal activity (-0.48 +/- 0.16 deltalog(10) CFU/ml/h). The excellent antibacterial activity of gemifloxacin was also confirmed by time-kill assays over 8 h in vitro.

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Figures

FIG. 1.
FIG. 1.
Gemifloxacin concentrations in serum and CSF over 8 h after intravenous injection of 15 mg of gemifloxacin/kg. The concentration of gemifloxacin in the CSF remained above the MIC (0.015 mg/liter) during the entire treatment period. As determined by comparison of serum and CSF AUCs, the penetration of gemifloxacin into inflamed meninges was 22%.
FIG. 2.
FIG. 2.
Gemifloxacin concentrations in serum and CSF over 8 h after intravenous injection of 30 mg of gemifloxacin/kg. The concentration of gemifloxacin in the CSF remained above the MIC (0.5 mg/liter) during almost the entire treatment period.
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