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Review
. 2002 May;76(10):4679-87.
doi: 10.1128/jvi.76.10.4679-4687.2002.

Viral late domains

Eric O Freed  1
Affiliations
Review

Viral late domains

Eric O Freed. J Virol. 2002 May.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Location of L domains in retroviral Gag proteins and in the matrix proteins of the rhabdoviruses and filoviruses. The retroviral Gag proteins that harbor L domains are shown in red; matrix, capsid, and nucleocapsid proteins are depicted in green, blue, and yellow, respectively. L domain motifs (PTAP, PPXY, and YXXL) are indicated.
FIG. 2.
FIG. 2.
EM analysis of HIV-1 L domain defects. (A) Effect of HIV-1 L domain mutation on virus budding. Virus expression was directed by WT pNL4-3 and a p6 mutant derivative truncated at p6 amino acid 1 (L1Term [36]). Budding from HeLa cells and the Jurkat T-cell line is shown. Adapted from reference . (B) Effect of TSG-5′ overexpression on HIV-1 budding. HeLa cells were transfected with pNL4-3 alone (WT) or cotransfected with pNL4-3 plus TSG-5′ (WT + TSG-5′). Adapted with permission from reference . In panels A and B, closed arrows indicate virus particles tethered to the plasma membrane; open arrows highlight virion-virion tethers. Bar, 100 nm.
FIG. 3.
FIG. 3.
Schematic organization of TSG101 and Nedd4. Domains (described in the text) are indicated. Diagram is not intended to be to scale.
See this image and copyright information in PMC

References

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    1. Babst, M., G. Odorizzi, E. J. Estepa, and S. D. Emr. 2000. Mammalian tumor susceptibility gene 101 (TSG101) and the yeast homologue, Vps23p, both function in late endosomal trafficking. Traffic 1:248-258. - PubMed
    1. Babst, M., B. Wendland, E. J. Estepa, and S. D. Emr. 1998. The Vps4p AAA ATPase regulates membrane association of a Vps protein complex required for normal endosome function. EMBO J. 17:2982-2993. - PMC - PubMed
    1. Bishop, N., and P. Woodman. 2000. ATPase-defective mammalian VPS4 localizes to aberrant endosomes and impairs cholesterol trafficking. Mol. Biol Cell. 11:227-239. - PMC - PubMed
    1. Bishop, N., and P. Woodman. 2001. TSG101/mammalian VPS23 and mammalian VPS28 interact directly and are recruited to VPS4-induced endosomes. J. Biol. Chem. 276:11735-11742. - PubMed

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