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. 1983 Apr 5;154(1):127-33.
doi: 10.1016/0014-5793(83)80888-6.

Kinetics of 5-enolpyruvylshikimate-3-phosphate synthase inhibition by glyphosate

M R Boocock  1 , J R Coggins
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Free article

Kinetics of 5-enolpyruvylshikimate-3-phosphate synthase inhibition by glyphosate

M R Boocock et al. FEBS Lett. .
Free article

Abstract

The herbicide glyphosate (N-phosphonomethyl glycine) is a potent reversible inhibitor of the 5-enolpyruvylshikimate-3-phosphate (EPSP) synthase activity of the purified arom multienzyme complex from Neurospora crassa. Inhibition of the EPSP synthase reaction by glyphosate is competitive with respect to phosphoenolpyruvate, with K(i) 1.1 microM, and uncompetitive with respect to shikimate-3-phosphate. The kinetic patterns are consistent with a compulsory order sequential mechanism in which either PEP or glyphosate can bind to an enzyme: shikimate-3-phosphate complex.

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