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Review
. 2002 Apr;2(4):385-7.
doi: 10.1016/s1534-5807(02)00158-2.

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity

W S Cook  1 , R H Unger
Affiliations
Free article
Review

Protein tyrosine phosphatase 1B: a potential leptin resistance factor of obesity

W S Cook et al. Dev Cell. 2002 Apr.
Free article

Abstract

Indirect evidence implicates leptin resistance in the pathogenesis of the lipotoxicity that complicates obesity and results in the metabolic syndrome. In this issue of Developmental Cell, two groups identify protein tyrosine phosphatase 1B (PTP1B) as a cause of leptin resistance through dephosphorylation of Jak2.

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