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. 2002 May 2;4(9):1411-4.
doi: 10.1021/ol017245g.

Carbamoyl-substituted N-heterocyclic carbene complexes of palladium(II): application to Sonogashira cross-coupling reactions

Robert A Batey  1 , Ming Shen, Alan J Lough
Affiliations

Carbamoyl-substituted N-heterocyclic carbene complexes of palladium(II): application to Sonogashira cross-coupling reactions

Robert A Batey et al. Org Lett. .

Abstract

[reaction: see text]. The first examples of N-carbamoyl-substituted heterocyclic carbene Pd(II) complexes are described. These thermal and hydrolytically stable complexes are readily prepared from carbamoyl imidazolium salts and efficiently promote Sonogashira cross-coupling reactions under mild conditions. Cesium carbonate is also shown to be an effective base for the coupling of aryl bromides.

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